Pioglitazone Reverses Alcohol-Induced Alveolar Macrophage Phagocytic Dysfunction
نویسندگان
چکیده
منابع مشابه
Alcohol Induced Mitochondrial Oxidative Stress and Alveolar Macrophage Dysfunction
An alcohol use disorder increases the risk of invasive and antimicrobial resistant community-acquired pneumonia and tuberculosis. Since the alveolar macrophage (AM) orchestrates the immune response in the alveolar space, understanding the underlying mechanisms by which alcohol suppresses AM phagocytosis is critical to improving clinical outcomes. In the alveolar space, chronic alcohol ingestion...
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Airway mucociliary clearance is a first-line defense of the lung against inhaled particles and debris. Among individuals with alcohol use disorders, there is an increase in lung diseases. We previously identified that prolonged alcohol exposure impairs mucociliary clearance, known as alcohol-induced ciliary dysfunction (AICD). Cilia-localized enzymes, known as the ciliary metabolon, are key to ...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2021
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.2000565